MMVSola Predictor
Basic Parameters
Advanced Parameters
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HUMAN PK DATA
% Human Plasma Binding (0-100)
Blood to Plasma Ratio
LogD (or LogP for bases)
Human Hep. CLint (µL/min/10^6 cells)
Human Mic. CLint (µL/min/mg)
ANIMAL PK DATA
RAT
% Plasma Binding (0-100)
Rat Plasma CL (mL/min/kg)
Plasma Vss in Rat (L/kg)
Rat Hep. CLint (µL/min/10^6 cells)
Rat Mic. CLint (µL/min/mg)
MOUSE
% Plasma Binding (0-100)
Mouse Plasma CL (mL/min/kg)
Plasma Vss in Mouse (L/kg)
Mouse Hep. CLint (µL/min/10^6 cells)
Mouse Mic. CLint (µL/min/mg)
DOG
% Plasma Binding (0-100)
Dog Plasma CL (mL/min/kg)
Plasma Vss in Dog (L/kg)
Dog Hep. CLint (µL/min/10^6 cells)
Dog Mic. CLint (µL/min/mg)
DOSING & PD DATA
Simulated Dose (mg)
NF54 72h IC50 (nM)
Hill Slope
Log10 in-vitro PRR / 48h
Molecular Weight (Da)
% Albumax Binding (0-100)
SCID EC50 [ng/mL]
Hill Slope in SCID
Predict the Dose
.
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HUMAN PK DATA
Fraction Absorbed (0 - 1)
10^6 cells/mL in Hep. Assay
Measured fu in Hep. assay (0-1)
Hepatocyte Correction Factor
mg/mL Protein in Mic. Assay
Measured fu in Mic. assay (0-1)
Microsome Correction Factor
ANIMAL PK DATA
RAT
Rat Blood to Plasma Ratio
10^6 cells/mL in Hep. Assay
Measured fu in Hep assay (0-1)
Rat Hep. Correction Factor
mg/mL Protein in Mic. Assay
Measured fu in Hep assay (0-1)
Rat Mic. Correction Factor
MOUSE
Mouse Blood to Plasma Ratio
10^6 cells/mL in Hep. Assay
Measured fu in Hep assay (0-1)
Mouse Hep. Correction Factor
mg/mL Protein in Mic. Assay
Measured fu in Hep assay (0-1)
Mouse Mic. Correction Factor
DOG
Dog Blood to Plasma Ratio
10^6 cells/mL in Hep. Assay
Measured fu in Hep assay (0-1)
Dog Hep. Correction Factor
mg/mL Protein in Mic. Assay
Measured fu in Mic. assay (0-1)
Dog Mic. Correction Factor
DOSING & PD DATA
Total Number of Doses
Dosing Interval (h)
Predict the Dose
.
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