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HUMAN PK DATA

% Human Plasma Binding (0-100)

Blood to Plasma Ratio

LogD (or LogP for bases)

Human Hep. CLint (µL/min/10^6 cells)

Human Mic. CLint (µL/min/mg)

ANIMAL PK DATA

RAT

% Plasma Binding (0-100)

Rat Plasma CL (mL/min/kg)

Plasma Vss in Rat (L/kg)

Rat Hep. CLint (µL/min/10^6 cells)

Rat Mic. CLint (µL/min/mg)

MOUSE

% Plasma Binding (0-100)

Mouse Plasma CL (mL/min/kg)

Plasma Vss in Mouse (L/kg)

Mouse Hep. CLint (µL/min/10^6 cells)

Mouse Mic. CLint (µL/min/mg)

DOG

% Plasma Binding (0-100)

Dog Plasma CL (mL/min/kg)

Plasma Vss in Dog (L/kg)

Dog Hep. CLint (µL/min/10^6 cells)

Dog Mic. CLint (µL/min/mg)

DOSING & PD DATA

Simulated Dose (mg)

NF54 72h IC50 (nM)

Hill Slope

Log10 in-vitro PRR / 48h

Molecular Weight (Da)

% Albumax Binding (0-100)

SCID EC50 [ng/mL]

Hill Slope in SCID

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HUMAN PK DATA

Fraction Absorbed (0 - 1)

10^6 cells/mL in Hep. Assay

Measured fu in Hep. assay (0-1)

Hepatocyte Correction Factor

mg/mL Protein in Mic. Assay

Measured fu in Mic. assay (0-1)

Microsome Correction Factor

ANIMAL PK DATA

RAT

Rat Blood to Plasma Ratio

10^6 cells/mL in Hep. Assay

Measured fu in Hep assay (0-1)

Rat Hep. Correction Factor

mg/mL Protein in Mic. Assay

Measured fu in Hep assay (0-1)

Rat Mic. Correction Factor

MOUSE

Mouse Blood to Plasma Ratio

10^6 cells/mL in Hep. Assay

Measured fu in Hep assay (0-1)

Mouse Hep. Correction Factor

mg/mL Protein in Mic. Assay

Measured fu in Hep assay (0-1)

Mouse Mic. Correction Factor

DOG

Dog Blood to Plasma Ratio

10^6 cells/mL in Hep. Assay

Measured fu in Hep assay (0-1)

Dog Hep. Correction Factor

mg/mL Protein in Mic. Assay

Measured fu in Mic. assay (0-1)

Dog Mic. Correction Factor

DOSING & PD DATA

Total Number of Doses

Dosing Interval (h)

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